What Is Wegovy
Wegovy is a prescription-only weight loss injection. The active ingredient in Wegovy™ is semaglutide, this is the same drug that is in Ozempic. The difference between Ozempic and Wegovy™ is that Ozempic is only licensed for use in diabetics and it comes in a different strength compared to Wegovy™, which comes in a single strength of 2.4mg.
The Wegovy™ (semaglutide) injection 2.4 mg is an injectable prescription medicine used for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems (e.g high blood pressure, type-2-diabetes, high cholesterol) to help them lose weight and keep the weight off.
- Wegovy™ should only be used with a reduced calorie meal plan and regular exercise. Wegovy™ alone will not reduce your weight if taken alone without any other life style adjustments.
- Wegovy™ contains semaglutide, a GLP-1 receptor agonist and should NOT be used in conjunction with other GLP-1 agonists such as Saxenda or Ozempic.
- There is insufficient data regarding whether taking Wegovy™ in conjunction with other prescription, over-the-counter or herbal weight loss products is safe and/or effective.
How Does Wegovy™ Work?
Wegovy™ (semaglutide 2.4mg) is a self injectable weight loss treatment. It contains the active ingredient semaglutide which is very similar to a naturally occuring hormone in the human body called Glucagon-Like Peptide 1 (GLP-1), which belongs to a family of hormones in the body called incretins.
After a meal GLP-1 is naturally released from your intestines to help regulate your blood sugar levels and reduce the amount of glucagon in your body. Glucagon is a naturally occurring hormone that works by inhibiting the action of insulin. As a result, it makes you feel less hungry, slows down the emptying of your stomach and makes you feel ‘fuller’ for longer.
In summary, Wegovy™ ‘tricks’ your body into producing more GLP-1 and therefore sends signals to your brain that you are full and do not need to eat.
How to use Wegovy
Wegovy (semaglutide) should be administered once a week on the same day. It can be taken at any time of day and with or without food. Subcutaneous injections into the abdomen, thigh, or upper arm are recommended.
For a total of 16 weeks, the Wegovy dose is increased every four weeks. This means that patients begin with a 0.25mg once-weekly dose and gradually increase it until they reach the maintenance dose of 2.4 mg once-weekly on week 17. This slow rise is critical since it reduces the possibility of negative effects. If adverse effects do occur, the majority will occur during the dose-escalation phase before improving.
Can Wegovy™ Help me Lose Weight?
The Step 1 clinical trial for Wegovy™ conducted by Novo Nordisk saw 1,961 patiens with with obesity (BMI ≥30 kg/m2) or with overweight (BMI 27 kg/m2-29.9 kg/m2)and at least 1 weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension. Patients received Wegovy™ or placebo in addition to instruction for a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended to a minimum of 150 min/week) throughout the trial.
The trial resulted in a satistically significant reduction in body weight when compared to the placebo after 68 weeks. The trial showed that there was an average reduction of 14.8% in body weight in patients taking Wegovy™ vs 2.8% reduction in body weight for those taking the placebo, the patients on the placebo only reduced their calorie intake and increased physical activity.
The results also indicated that after 68 weeks on Wegovy™, 83.5% of patients lost 5% or more of their body wieght. In the placebo group, 31.1% of patients lost 5% or more. Further clinical trials were also carried out, which showed statistically significant reductions in body weight.
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